维生素B6状态与肝纤维化之间的关联:来自NHANES 2005-2010年的证据
Junlu Peng1,2, Wenjun Zhang2, Meng Pan3
1Department of Hepatobiliary Surgery, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Frontiers in nutrition
|August 21, 2025
概括
高水平的酸盐与肝纤维化风险的降低相关. 相反,高的4-氧酸 (4-PA) /PLP比率表明维生素B6代谢增加和LF风险增加.
科学领域:
- 肝病学
- 营养生物化学
- 慢性疾病流行病学
背景情况:
- 肝纤维化 (LF) 是一个日益严重的全球健康问题,
- 在炎症期间维生素B6的代谢发生变化,并与糖尿病和高血压等疾病有关.
- 维生素B6与LF风险之间的关系尚未被研究.
研究的目的:
- 调查维生素B6代谢物 (4- 皮里多克酸 [4- PA],皮里多克素-5- 酸盐 [PLP]) 和它们与肝纤维化风险的关系.
- 探索维生素B6作为潜在的肺炎风险生物标志物.
主要方法:
- 使用了国家健康和营养检查调查 (2005-2010) 的数据.
- 使用血清中的4-PA和PLP水平以及4-PA/PLP比率来评估维生素B6状态.
- 使用后勤回归分析来确定维生素B6状态和LF之间的关联,调整共变量并进行子组分析.
主要成果:
- 高血清PLP水平与较低的LF风险显著相关 (OR=0.44,p<0.001).
- 较高的4-PA/PLP比率表明维生素B6代谢速度较快,与较高的LF风险有关 (OR=2. 69, p<0. 001).
- 没有观察到4-PA水平与LF风险之间的显著关联;研究结果在各小组中一致.
结论:
- 较高的血清PLP水平与肝纤维化发生的几率降低有关.
- 增加的4-PA/PLP比率反映了维生素B6的加速代谢,与肝纤维化发生的可能性增加有关.
- 这些发现突显了维生素B6代谢在肝纤维化病变中的潜在作用.
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