氧化平衡得分与心血管 - - 代谢综合征和全因死亡率之间的关联
在PubMed上查看摘要
概括
此摘要是机器生成的。较高的氧化平衡得分 (OBS) 与较少的晚期心血管-脏-代谢 (CKM) 阶段和较低的死亡风险有关. 这表明控制氧化应激可能有助于控制CKM综合征的进展并改善结果.
科学领域
- 代谢综合征研究
- 心血管健康
- 病流行病学
- 氧化应激机制
背景情况
- 心血管 - - 代谢综合症 (CKM) 由于其多阶段性质而构成重大公共卫生挑战.
- 通过氧化平衡评分 (OBS) 评估的氧化应激是评估CKM综合征进展的新因素.
- 了解OBS和CKM阶段之间的联系对于制定有效的管理策略至关重要.
研究的目的
- 研究氧化平衡评分 (OBS) 与心血管--代谢综合征 (CKM) 的晚期阶段之间的关联.
- 在CKM综合征的背景下,研究OBS与全因死亡率之间的关系.
- 通过有限的立方线分析探索潜在的非线性关联.
主要方法
- 使用了美国30-79岁的12793名成年人的国家健康和营养检查调查 (NHANES) 的数据.
- 从20个与氧化应激相关的成分中使用已确定的标准和计算的OBS来分类CKM综合征阶段.
- 使用逻辑回归和Cox比例危险模型,限制立方线,分析与CKM阶段和死亡率的关联.
主要成果
- 较高的OBS与晚期CKM阶段呈反向关联 (OR T3: 0.58).
- 在所有CKM阶段,OBS与全因死亡率之间发现了显著的反向关系 (HR T3非高级:0. 58;HR T3高级:0. 62).
- 限制的立方脊柱分析证实了剂量反应关系,表明较高的OBS与死亡风险降低相关.
结论
- 增加的OBS对晚期CKM综合征的进展起着保护作用.
- 在CKM综合征患者中,较高的OBS与全因死亡风险降低有关.
- 通过针对OBS的策略调节氧化应激可能是治疗CKM综合征的有希望的方法.
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