维生素D缺乏和周围假肢骨折
Emily M Pilc1, Amy Y Zhao2, Sanjay Kubsad3
1Eastern Virginia Medical School at Old Dominion University, 825 Fairfax Ave, Norfolk, VA, 23507, USA.
Journal of clinical orthopaedics and trauma
|August 21, 2025
概括
在全关节整形术 (THA) 或膝关节整形术 (TKA) 后,维生素D缺乏并没有增加术后周围假肢骨折 (PPF) 的风险. 这项研究没有发现维生素D水平与PPF发生率或修订风险之间的关联.
科学领域:
- 骨科手术
- 营养科学
- 流行病学
背景情况:
- 手术后的周围假肢骨折 (PPF) 是关节整形手术 (THA) 和膝关节整形手术 (TKA) 后的一个重大并发症.
- 维生素D缺乏是骨质疏松症的潜在危险因素,与PPF有关.
- 之前的假设表明,在患有PPF的患者中,维生素D缺乏的患病率很高.
研究的目的:
- 在THA或TKA后的10年内调查维生素D缺乏症患者的PPF累积发病率和风险.
- 评估维生素D状态与PPF发生之间的关联.
- 确定维生素D缺乏是否会影响由于PPF而需要修复手术.
主要方法:
- 使用TriNetX研究网络进行了回顾性队列分析.
- 在2010年1月至2021年4月期间接受初级THA或TKA治疗的患者,可获得的血清二醇水平和至少两年的随访数据.
- 使用倾向性评分匹配以比较1:1的维生素D缺乏症患者和没有维生素D缺乏症患者.
主要成果:
- 这项研究共包括15226名患者.
- 与对照组相比,维生素D缺乏群体中PPF的累积发病率较低,无论是THA (0. 60% vs 1. 68%) 还是TKA (0. 26% vs 0. 47%).
- 在THA (HR: 0. 69) 或TKA (HR: 0. 80) 后,维生素D缺乏与PPF风险之间没有发现统计学意义上的关联.
结论:
- 在全关节或膝关节整形术后,维生素D缺乏与术后周围假肢骨折的发生率或风险增加无关.
- 这项研究没有发现维生素D缺乏与PPF导致的修复手术风险之间的相关性.
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