孕妇中新兴和传统的与交通有关的含有的有机化合物:暴露水平,季节性变化和健康风险
Lin Tao1, Nan Sun1, Yahong Wei2
1School of Public Health and Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei 230032, China.
Environment & health (Washington, D.C.)
|August 21, 2025
概括
孕妇暴露于与交通有关的含有的有机化合物 (TNOC),常见的化学物质包括2-基和6PPD-Q. 对这些TNOC的暴露与胎儿出生体重的不良影响有关.
科学领域:
- 环境化学
- 毒理学
- 公共卫生
背景情况:
- 城市交通污染正在随着排放控制技术和电动汽车的发展而变化.
- 与交通有关的含有的有机化合物 (TNOC) 是关键的但研究不足的污染物.
- 敏感人群,如孕妇,需要进行特定的暴露评估.
研究的目的:
- 评估孕妇对20种新兴和传统的TNOC的内部暴露.
- 确定常见的TNOC及其潜在来源.
- 研究TNOC暴露与胎儿发育之间的关联.
主要方法:
- 分析了400名孕妇的尿液样本.
- 20种特定TNOC的量化,包括2-基二醇 (2-OH-BTH),6PPD-Q和托利二醇 (TTR).
- 统计分析以确定相关性,起源,季节性变化和健康关联.
主要成果:
- 经常检测到TNOCs (中位数 ΣTNOCs: 34.7 ng/ mL),其中2-OH-BTH,6PPD-Q和TTR是最常见的.
- 对于PPD和尼特罗PAH的来源有所不同.
- 在经常通勤的人群中观察到更高的BTH,TCMTB和XTR水平,冬季的TNOC负担更高.
- 估计每天通过尿液排泄的 ΣTNOC 的中位数为 978 ng/ kg/ day.
结论:
- 孕妇暴露于各种TNOC,这表明非排气排放可能增加.
- 暴露于特定的TNOC如6PPD,TPG和2-OH-BTH与胎儿出生体重有负面关联.
- TNOC对胎儿发育构成潜在的健康风险,需要进一步的研究和缓解策略.
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