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相关概念视频

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
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对口腔状细胞癌的先进药物输送系统:基于纳米技术和其他创新方法的全面审查

Alain Herrada Céspedes1,2,3, Montserrat Reyes4, Javier O Morales1,2,3

  • 1Drug Delivery Laboratory, Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, Universidad de Chile, Santiago, Chile.

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概括

先进的药物输送系统 (DDS) 在治疗侵袭性口腔癌 (OSCC) 方面具有前景. 这些使用纳米技术和人工智能的向疗法旨在提高有效性并减少副作用,尽管仍然存在挑战.

关键词:
药物输送系统免疫疗法智能水凝脂质纳米粒子纳米技术在口腔癌症口腔状细胞癌光动力疗法

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科学领域:

  • 癌症学
  • 生物材料科学
  • 纳米技术

背景情况:

  • 口腔状细胞癌 (OSCC) 是具有攻击性,转移性和耐治疗性的.
  • 传统的OSCC治疗方法面临重大局限性.

研究的目的:

  • 审查口腔癌的最新药物输送系统.
  • 突出OSCC治疗的DDS的进展和未来方向.

主要方法:

  • 对OSCC的DDS最近文献的审查.
  • 专注于纳米技术,智能水凝,脂质纳米粒子和光动力疗法 (PDT).
  • 包括微电机系统 (MEMS) 和人工智能 (AI) 等新兴技术.

主要成果:

  • DDS利用瘤特异性刺激 (pH,ROS,酶) 进行向释放.
  • 组合疗法 (化疗,PDT,免疫疗法) 显示出潜力.
  • MEMS和人工智能提高了DDS的精度和个性化.

结论:

  • DDS为OSCC提供创新解决方案,改善向治疗并降低毒性.
  • 跨学科合作对于克服可扩展性,定制性和安全性方面的挑战至关重要.
  • 未来的研究应专注于改善OSCC患者的治疗结果和生活质量.