结直肠癌患者的饮食和身体活动:随机对照研究的研究方案
Ali Mohamed Aboturkia1, Wala Ben Kridis2, Mukhtar Omer Aqoup3
1Department of Pathology, Azzaytuna University, Tarhuna 3022, Libya.
World journal of gastrointestinal oncology
|August 21, 2025
概括
包括饮食和体力活动 (PA) 在内的结构化生活方式干预措施有望改善结直肠癌 (CRC) 幸存者的结果. 本研究将评估它们对无病存活率和整体存活率 (OS) 的影响.
科学领域:
- 癌症学
- 公共卫生
- 生活方式医学
背景情况:
- 结直肠癌 (CRC) 幸存者的数量越来越多,需要基于证据的治疗后策略.
- 对于没有疾病的CRC幸存者的最佳营养和体力活动 (PA) 准则尚未确定.
- 生活方式因素与癌症结局有关, 但对生存护理缺乏共识.
研究的目的:
- 在CRC幸存者中评估结构化饮食和PA干预措施的有效性.
- 确定这些干预措施是否改善行为目标,无疾病生存率和整体生存率 (OS).
- 为将生活方式干预措施纳入临床实践提供特定区域的证据.
主要方法:
- 第二阶段随机对照试验采用2x2因数设计.
- 从利比亚和突尼斯招募300名完全康复的CRC幸存者
- 随机分为四组:联合干预,仅饮食,仅PA或通常护理,持续24个月.
主要成果:
- 研究将分析结果,包括无病存活率,整体存活率和生活质量.
- 在ClinicalTrials.gov (NCT06194786) 获得伦理批准并注册试验.
- 数据收集和分析将为24个月的干预有效性提供洞察力.
结论:
- 这项研究旨在证明生活方式干预的可行性和有效性.
- 评估高纤维,低红肉的饮食和结构化PA以改善生存结果.
- 这些发现将支持将这些生活方式行为纳入未来的临床指导方针.
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