在未接受药物治疗的强迫症患者群体认知行为治疗后,网络间和网络内连接性降低
Zong-Feng Zhang1,2, Yan He1,2, Yu-Qiu Su1,2
1Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang Province, China.
World journal of psychiatry
|August 21, 2025
概括
在强迫症患者中,群体认知行为疗法 (GCBT) 改善了大脑连接. 关键网络的功能连接性下降与增强的认知功能相关,为治疗反应提供潜在的神经成像标志物.
科学领域:
- 神经科学
- 精神病学
- 认知科学
背景情况:
- 群体认知行为治疗 (GCBT) 是强迫症的有效治疗方法.
- 在强迫症患者的GCBT后,大脑网络内部和大脑网络之间的功能连接 (FC) 变化尚不清楚.
研究的目的:
- 在GCBT之前和之后,对未服用药物的强迫症患者的认知网络进行休息状态功能连接 (rs-FC) 异常的研究.
- 通过评估 rs-FC 和认知功能的变化来验证 GCBT 的治疗效果.
主要方法:
- 在33名强迫症患者和26名健康人群中进行了休息状态功能磁共振成像 (rs- fMRI).
- 强迫症患者在12周的GCBT干预之前和之后接受了rs- fMRI.
- 在默认模式网络 (DMN),背部注意网络 (DAN),突出网络 (SAN) 和前端平行网络 (FPN) 之间分析了FC. 神经心理测试评估记忆,执行功能,注意力和视觉空间能力.
主要成果:
- 在GCBT后,DMN和DAN内部以及DMN-DAN,DMN-FPN,DMN-SAN和DAN-SAN网络之间观察到 rs-FC的显著下降.
- 包括记忆,执行功能,注意力和视觉空间能力在内的认知功能在治疗后显著改善.
- 减少的DMN rs-FC与改善的执行功能和视觉空间能力相关. 其他网络变化与特定的认知测试表现相关.
结论:
- 在强迫症患者中,GCBT导致网络间和网络内 rs- FC 的显著变化.
- 在DMN和DAN内的rs-FC降低,特别是与执行功能相关联时,可以作为神经成像生物标志物来预测强迫症的GCBT反应.
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