更新NSAID过敏反应的分类和常规诊断:一个WAO声明
Antonino Romano1, Rocco L Valluzzi2, Emilio Alvarez-Cuesta3
1Oasi Research Institute - IRCCS, Troina, Italy & BIOS S.p.A. Società Benefit, Rome, Italy.
The World Allergy Organization journal
|August 21, 2025
概括
这项研究更新了对非类固醇抗炎药物 (NSAIDs) 的过敏反应的分类,包括混合和与食物相关的过敏症. 它建议将NSAID诱导的疹/血管/过敏症 (NIUAA) 的缩写扩展到成年人.
科学领域:
- 过敏和免疫学
- 药理学
- 临床医学
背景情况:
- 非类固醇抗炎药物 (NSAID) 的过敏反应分为即时或延迟的.
- 直接反应包括NSAID加剧的呼吸系统疾病 (N-ERD),NSAID加剧的皮肤疾病 (NECD),NSAID诱导的疹/血管 (NIUA) 和单次NSAID诱导的疹/血管/过敏症 (SNIUAA).
- 目前的分类没有完全解决影响多个器官系统的"混合"反应或NSAID加剧的食物过敏.
研究的目的:
- 更新NSAID过敏反应的分类和诊断.
- 包括新的反应类型,包括混合反应和NSAID加剧的食物过敏.
- 建议将NIUAA的缩写扩展到成年患者.
主要方法:
- 对现有文献和临床观察进行审查和综合.
- 对各种NSAID过敏现象的诊断标准的分析
- 开发一个修订的分类框架.
主要成果:
- 在NIUA标准中确定涉及多个器官系统的"混合"反应.
- 承认NSAID加剧的食物过敏 (NEFA) 和NSAID诱导的食物过敏 (NIFA) 是不同的实体.
- 建议将NIUAA扩展到成人过敏反应.
结论:
- 需要更新NSAID过敏的分类,以包括混合反应和NSAID食物过敏.
- 需要修订诊断标准和术语,以准确管理患者.
- 拟议的NIUAA扩展分类旨在改善成人严重NSAID反应的识别和治疗.
相关概念视频
Allergic Reactions
26.4K
Overview
26.4K
Pharmacovigilance
2.0K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
2.0K
Allergic Drug Reactions
1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Drug Toxicity: Allergic Reactions
209
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
209
Allergic Reactions: Anaphylaxis
280
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
280
Angina II: Classification
709
Angina, also known as angina pectoris, is a chest pain resulting from diminished blood flow to the heart muscle and is often a symptom of coronary artery disease. Angina presents several variants with distinctive attributes, etiologies, and therapeutic approaches. The main types of angina include stable, unstable, variant (Prinzmetal's), microvascular, intractable, and silent ischemia.Stable angina is caused by atherosclerosis, which leads to the formation of plaques that narrow the coronary...
709


