导航事件的记忆和其早期衰退的基础是正确的皮质-海马体动态
Jaeseob Lim1, Sang-Eon Park1, Sang-Hun Lee1
1Department of Brain and Cognitive Sciences, Seoul National University, Gwanak-gu, Seoul, Republic of Korea.
Imaging neuroscience (Cambridge, Mass.)
|August 21, 2025
概括
大脑中的正规神经动力学
科学领域:
- 神经科学
- 认知科学
- 神经成像
背景情况:
- 成功的导航依赖于与地标和转相关的感知信息的动态处理.
- 导航记忆和与年龄相关的下降的个体差异可能源于皮质-海马网络动态的偏差.
研究的目的:
- 调查正规神经动态如何代表个体间的导航体验.
- 探索大脑活动和导航记忆性能之间的个人与正规相似性 (ICS).
- 确定衰老在神经动态中的作用及其对认知功能的影响.
主要方法:
- 76名参与者 (年轻人和老年人) 观看虚拟导航视频的fMRI扫描.
- 通过平均参与者的神经活动来计算正规动态.
- 测量个人与规范相似性 (ICS) 和主体间功能连接性 (ISFC).
主要成果:
- 在视觉流和 precuneus 中观察到的最高 ICS 与信息导航事件相关.
- 中间叶 (MTL) ICS 和海马皮层协调与空间记忆性能相关.
- 在MTL和皮质动力学之间降低的ISFC调解了衰老对认知表现的影响.
结论:
- 规范的神经动力学提供了对空间时间延伸事件处理的洞察力.
- 中间叶 (MTL) 连接和规律动态对于导航和情节性记忆至关重要,特别是在衰老中.
- 皮质-海马网络的规范动态偏差会影响导航记忆,并且会受到老化的影响.
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