不受监管的关节炎补充剂的不良影响和患者感知:安全网初级保健诊所的回顾性混合方法研究
Vi D Nguyen1, Elizabeth M Canales2, Kenneth Pettersen2
1Department of Medicine, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.
Cureus
|August 21, 2025
概括
使用非处方关节炎补充剂的患者没有意识到像德克萨米这样的隐藏药物会显著缓解疼痛,但也会出现包括上腺功能不足在内的不良反应. 许多人在医生建议后停止使用.
科学领域:
- 药理学
- 公共卫生
- 患者安全
背景情况:
- 补充和替代药物的使用是常见的慢性疼痛.
- 无处方 (OTC) 关节炎补充剂通常被宣传为天然药物,但可能含有未公开的处方药.
- 如果没有临床监督,隐藏的药物成分会给健康带来重大风险.
研究的目的:
- 调查患者使用非处方关节炎补充剂的经验,感知和动机.
- 了解为什么患者使用这些补充剂尽管FDA的警告和潜在的危害.
- 评估患者对隐藏成分和相关风险的认识.
主要方法:
- 临床医生发现患者使用FDA警告的OTC关节炎补充剂.
- 半结构化的电话采访评估了患者报告的数据.
- 对临床数据和皮质醇水平进行了分析.
主要成果:
- 12名患者报告使用含有未公开药物的Artri King类补充剂 (德克萨米他松,迪克洛菲纳克,梅托卡巴摩尔).
- 其中的动机包括推,处方治疗的缓解不足,以及自然安全感.
- 在3/5的受试者中,患者经历了疼痛缓解,但报告了副作用,包括上腺功能不足;没有人知道隐藏的成分.
结论:
- 患有慢性疼痛的患者继续使用OTC补充剂,因为他们认为安全性和常规治疗不足,而不知道隐藏的药物风险.
- 补充剂中未公开的成分会导致严重的不良事件,包括上腺功能衰竭和心血管问题.
- 临床医生必须对补充剂使用进行查,教育患者风险,并推广更安全的疼痛管理策略.
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