实施类型和选方法,以取代传统的抗球蛋白交叉匹配程序,在第三级护理医院的可选方案中进行兼容性测试
I Suresh Kumar1, Rajendra G Kulkarni1, Dibyajyoti Sahoo1
1Department of Transfusion Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Asian journal of transfusion science
|August 21, 2025
概括
类型和查 (T和S) 协议是对抗体查阴性接受者的安全和有效的输血前检测方法. 实施T和S可以降低交叉匹配输血比率并改善库存管理.
科学领域:
- 输血医学
- 血液储存
- 免疫学
背景情况:
- 输血前的检测对于安全的输血至关重要,防止血液溶解反应.
- 类型和查 (T和S) 协议为抗体查阴性接受者提供了一种有效的方法.
- 这项研究评估了T和S协议在机构环境中的可行性.
研究的目的:
- 为了比较T和S协议与选择性包装红细胞 (PRBC) 输血的抗人类球蛋白 (AHG) 阶段交叉匹配.
- 根据T和S协议发布的PRBC单元的安全性和兼容性.
- 评估T和S实施对实验室效率和库存管理的影响.
主要方法:
- 对有输血或怀孕史的患者的选择性血液样本进行了横截面分析研究.
- 849个样本接受了抗体查;抗体查阴性样本使用直接盐水阶段进行交叉匹配,以发放PRBC单位.
- 对所有样本使用AHG相交对进行了验证.
主要成果:
- 在14705名PRBC请求中,有849名患者有输血或怀孕史;没有人呈阳性抗体查结果.
- 1028个PRBC单位是液交叉匹配的,677个是根据T和S协议发放的.
- 在T和S方法和AHG阶段交叉匹配之间观察到完美的一致性,在抗体查呈阴性时没有发现不兼容性. 交叉匹配输血比率从2.1降至1.5.
结论:
- 该T和S协议与选择性输血的AHG相交对完全一致.
- 推采用T和S方法进行选择性血液请求,以优化劳动力利用率和库存管理.
- 该T和S协议确保了对抗体查阴性接受者的安全和兼容的PRBC输血.
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