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Updated: Sep 10, 2025

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

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通过实证和混合模拟药物-聚合物可溶性和可混性来推进无形固体分散:使用Ibuprofen的案例研究

Matheus de Castro1, Ana Sara Cordeiro1, Mingzhong Li1

  • 1Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, United Kingdom.

International journal of pharmaceutics: X
|August 21, 2025
PubMed
概括

这项研究使用建模和DSC评估了四种聚合物的易布洛芬溶解性. 在较高的药物负载下,KOL17PF显示出最好的兼容性,而HPMCAS对无形固体分散 (ASD) 的稳定性有限.

关键词:
无形固体分散 (ASD)玻璃过渡点压缩 (MPD)扰乱链统计相关流体理论 (PC-SAFT)阶段图

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