使用计算机断层成像和同时测压的大量皮下注射的特征
Mona Purcell1, Sahab Babaee2, Michael Galluppi2
1Translational Imaging, Merck Research Laboratories, Merck and Co., Inc., Rahway, NJ, United States.
Frontiers in drug delivery
|August 21, 2025
概括
在小型猪中使用新的成像和压力测量方法来评估大量的皮下注射. 通过降低压力和增加血分散,氨酸酶提高了注射耐受性.
科学领域:
- 生物制药配方
- 药物输送系统
- 医学成像
背景情况:
- 生物药物正在转向皮下注射,
- 由于溶解度的限制,需要大量注射 (大于2毫升).
- 提高大量皮下注射的耐受性至关重要.
研究的目的:
- 开发和验证一种用于同时表征皮下注射和压力的方法.
- 评估注射量和氨酸酶对注射参数的影响.
主要方法:
- 在小猪中开发计算机断层扫描 (CT) 图像技术,以分析血栓形态.
- 集成的压力传感器可以测量注射时的皮下压力.
- 测试了两种注射量 (4. 5毫升和9毫升) 含有和没有氨酸酶.
主要成果:
- 注射参数,包括血栓形态和皮下压力,与注射量有显著差异.
- 氨酸酶的含有导致了血分散的增加和皮肤膨胀的减少.
- 与氨酸酶联合配方明显降低了注射压力.
结论:
- 开发的CT成像和内线压力测量方法提供了皮下注射的全面评估.
- 这种新的方法对于评估不同的注射策略和配方非常有价值.
- 这些发现支持使用氨酸酶来提高大量皮下生物输送的耐受性.
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