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Updated: May 6, 2026

Measuring RAN Peptide Toxicity in C. elegans
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在致病值时,多重氨酸的表达稍微增加了tau的神经毒性和蛋白质积累. 优雅的

Joshua C Hincks1, Jade G Stair1, Nicole F Liachko1,2

  • 1Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington, United States.

microPublication biology
|August 21, 2025
PubMed
概括

亨廷顿病 (HD) 涉及有毒的多胺 (polyQ) 蛋白质. 在C. elegans中与polyQ同时表达tau会恶化运动缺陷,这表明tau病理可能会影响HD的进展,特别是边缘重复长度.

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