患有急性瘤性胰腺炎的危急病患者的细胞大脑病毒活性化
Umadri Singh1, Mohan Gurjar1, Atul Garg2
1Department of Critical Care Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India.
在三分之一的急性亡性胰腺炎 (ANP) 患者中发生了细胞巨化病毒 (CMV) 活性化. 较高的CMV病毒载荷与较差的临床结果相关,突出显示了严重病患者的显著关联.
科学领域:
- 传染性疾病
- 危急护理医学
- 病毒学
背景情况:
- 越来越多地发现细胞巨病毒 (CMV) 再激活在重症患者中,即使这些患者看起来没有免疫功能受损.
- 之前没有对急性死性胰腺炎 (ANP) 患者进行过CMV再激活研究.
研究的目的:
- 研究成年ANP患者中CMV再激活的发生率和临床意义.
- 确定CMV病毒载量与ANP患者的临床结果之间的关联.
主要方法:
- 一项前性队列研究,涉及入院于ICU的成年ANP患者.
- 每周分析血,排液含量和死组织样本的CMVDNA.
- 被定义为血病毒载量> 1000副本/毫升的CMV重新激活.
主要成果:
- 在31. 7%的ANP患者中检测到CMV的重新激活.
- 患有CMV重新激活的患者的腹腔和血液感染率较高.
- 与幸存者相比,在血和排水样本中观察到较高的CMV病毒载荷.
结论:
- 大约三分之一的ANP患者经历了CMV的重新激活.
- 高度和持续的CMV病毒载荷与ANP的较差临床结果有关.
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