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在自身免疫性甲状腺功能低下症中,牙周参数与甲状腺标志物之间的关联:横截面研究
Sunitha Puthiyapurayil1, Rosamma Joseph Vadakkekuttical2, Thulaseedharan Nallaveettil Kesavan3
1Department of Periodontics, Government Dental College, Thrissur, Affiliated to Kerala University of Health Sciences, Thrissur, Kerala, India.
Journal of periodontology
|August 21, 2025
概括
患有自身免疫性甲状腺功能低下症的人患有严重牙周病的风险更高. 这项研究发现甲状腺功能障碍标志物,如抗甲状腺过氧化酶 (抗TPO) 抗体与牙周组织损失增加之间存在显著联系.
科学领域:
- 内分泌学
- 牙周病学
- 免疫学
背景情况:
- 炎症性细胞因子与自身免疫性甲状腺功能低下和牙周病的发病有关.
- 累积的炎症标志物可能有助于严重的牙周病变.
研究的目的:
- 在自身免疫性甲状腺功能低下患者中评估牙周炎的患病率和严重程度.
- 与甲状腺标记物 (抗TPO抗体,T3,T4,TSH) 和C反应蛋白 (CRP) 相关联的临床附着损失 (CAL) 和牙周炎表面积 (PISA).
主要方法:
- 这是一项横截面研究,将65名接受治疗的自身免疫性甲状腺功能低下患者与75名全身健康患者进行比较.
- 牙周参数 (BoP,PPD,CAL,OHI-S,PI,PISA) 和全身参数 (T3,T4,TSH,抗TPO抗体,CRP) 的评估.
- 使用未配对的t测试和奇方测试进行数据分析.
主要成果:
- 在自身免疫性甲状腺功能低下组中,牙周炎的发病率和严重程度显著增加 (p < 0. 001).
- 在自身免疫性甲状腺功能低下患者中,CAL,PISA,T3,TSH和抗TPO抗体水平升高.
- 平均CAL和PISA与抗TPO抗体,T3,T4,TSH和CRP之间的正相关性. 与平均CAL显著相关的抗TPO抗体 (β = 0. 001, p = 0. 02).
结论:
- 自免疫性甲状腺功能低下患者出现牙周炎的发病率和严重程度增加.
- 在自身免疫性甲状腺功能低下组中观察到较高的BoP,PPD,CAL和PISA水平.
- 在CAL,PISA和甲状腺相关标志物 (抗TPO抗体,T3,TSH,CRP) 之间发现了显著的正相关性.
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