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研究领域生物医学和临床科学瘤学和致癌症预测和预后标志物
用于诊断和治疗乳腺癌的DNA甲基化生物标志物:我们现在处于何处?

用于诊断和治疗乳腺癌的DNA甲基化生物标志物:我们现在处于何处?

Sarah Williams ^1,2, Susan J Clark ^1,2, Ruth Pidsley ^1,2, Clare Stirzaker ^1,2

Sarah Williams ^1,2, Susan J Clark ^1,2, Ruth Pidsley ^1,2

¹Epigenetics Research Laboratory, Cancer Ecosystems Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.
²School of Clinical Medicine, UNSW Medicine and Health, Sydney, NSW, Australia.

⁰Epigenetics Research Laboratory, Cancer Ecosystems Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.

Epigenomics +

|

2025年八月21日

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在PubMed上查看摘要

概括

此摘要是机器生成的。

DNA甲基化生物标记可以改善乳腺癌的治疗. 这些稳定的修饰可以帮助诊断,预测治疗反应,并通过液体活检监测疾病.

科学领域

癌症学
分子生物学
生物标志物发现

背景情况

乳腺癌是全球主要的癌症,需要改进临床决策工具.
DNA甲基化变化是瘤发生的早期,稳定的事件,使它们成为有吸引力的生物标记物.
目前的乳腺癌管理需要可靠的风险评估方法,治疗反应预测和患者监测.

研究的目的

审查DNA甲基化在乳腺癌中的作用.
探索DNA甲基化生物标志物的临床实用性,用于各种乳腺癌管理方面.
讨论这些生物标志物的未来潜力,特别是在液体活检中.

主要方法

专注于乳腺癌中DNA甲基化的文献审查.
对基于组织和血液的DNA甲基化生物标志物的当前研究分析.
讨论方法和生物信息工具的进展.

主要成果

在乳腺癌诊断,亚型和预测化疗,内分泌疗法和免疫疗法的过程中,DNA甲基化生物标志物取得了显著进展.
这些生物标志物显示出预后评估和理解瘤微环境的潜力.
液体活检平台和循环瘤DNA (ctDNA) 测试为临床整合提供了有前途的途径.

结论

DNA甲基化生物标志物是促进多种临床模式的乳腺癌治疗的宝贵工具.
与液体活检和ctDNA测定等先进技术的整合是广泛临床采用的关键.
持续的研究和开发对个性化乳腺癌治疗和监测具有重大前景.

关键词:

DNA 甲基化生物标志物乳腺癌循环中的瘤DNA 检测情况表观遗传学预后情况治疗方法

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相关概念视频

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

In most mammals, females have two X chromosomes (XX) while males have an X and a Y chromosome (XY). The X chromosome contains significantly more genes than the Y chromosome. Therefore, to prevent an excess of X chromosome-linked gene expression in females, one of the two X chromosomes is randomly silenced during early development....

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