多组单细胞分析揭示了早期感染中HIV-1持续性和异常宿主免疫反应的关键调节者

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Dayeon Lee1, Sin Young Choi1, So-I Shin1

  • 1School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.

eLife
|August 21, 2025
PubMed
概括

人类免疫缺陷病毒-1 (HIV-1) 在早期感染期间会损害T细胞的免疫反应. 这项研究显示,Th17细胞中的KLF2驱动病毒的持续性,并阻碍抗病毒防御.

关键词:
艾滋病毒急性感染人类感染性疾病微生物学单细胞ATAC测序单细胞RNA测序病毒

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