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基于LAPONITE®的纳米载体在药物输送应用中的进步

Jude Onojah¹, Weldejeworgis Gebrehiwot¹, Dharmaraj Raghavan¹

¹Department of Chemistry, Howard University, Washington, DC 20059, USA. draghavan@howard.edu.

Biomaterials science

|August 21, 2025

概括

这项研究探讨了基于LAPONITE®的纳米颗粒药物递送系统 (NDDS) 的治疗应用. 这些智能纳米载体提供由外部刺激触发的可控药物释放,

科学领域:

材料科学
纳米技术
制药公司

背景情况:

聚合物纳米复合材料在制药领域越来越受欢迎.
拉波尼特 (LAPONITE) 是一种多用途的粘土矿物质,具有药物输送潜力.

研究的目的:

提供基于LAPONITE®的纳米颗粒药物输送系统 (NDDS) 的概述.
讨论物理化学特性,药物封装,释放因子,生物降解性和稳定性.
突出各种疗法和大分子的应用.

主要方法:

基于LAPONITE®的纳米复合材料系统的全面审查.
分析LAPONITE®,聚合物和药物之间的相互作用.
对刺激反应的药物释放机制的检查 (pH,温度,光,磁场).

主要成果:

LAPONITE®纳米载体显示药物释放受控.
有效封装抗癌,抗生素和抗炎剂,以及大分子和蛋白质.
从LAPONITE®纳米载体中释放药物的证据.

结论:

基于LAPONITE®的NDDS提供可调节的药物输送特性.
多功能,对刺激有反应的纳米载体具有智能和可控药物输送的巨大潜力.
这些系统为治疗慢性疾病提供了有前途的途径.

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