基于氧化物纳米酶的复杂菌根系统用于牙周炎的骨重塑和ROS扫除
Yue Xu1,2, Ning Huang1,2, Lisha Pan1,2
1Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai, 200011, China.
Advanced healthcare materials
|August 21, 2025
概括
一种新型的菌根系统提供纳米酶和酸来对抗牙周炎. 这种治疗可以减少炎症,抗击感染,并通过清除活性氧物种 (ROS) 来促进组织再生.
科学领域:
- 生物材料科学
- 纳米技术
- 牙周病学
背景情况:
- 牙周炎是一种慢性炎症性牙疾病,由牙斑和过度反应性氧物种 (ROS) 驱动.
- 现有的治疗方法难以解决持续的炎症并实现组织再生.
- 牙周炎的氧化应激有助于疾病的进展和组织损伤.
研究的目的:
- 开发一种可响应ROS的多功能菌根系统 (HA-PMs@Ce) 用于向性牙周炎治疗.
- 研究氧化物 (CeOx) 纳米酶和酸 (TA) 在体系统中的治疗潜力.
- 评估该系统在减少炎症,抗击感染和促进组织再生方面的有效性.
主要方法:
- 使用块共聚合物 (PLLA-b-PLys/PBA),酸 (TA),氧化 (CeOx) 纳米酶和酸 (HA) 涂层自组装构建了一个多功能菌根系统 (HA-PMs@Ce).
- 使用ROS敏感的酸结合和静电相互作用来实现细胞稳定性和按需释放药物.
- 评估了该系统对ROS清除,抗菌活性,巨分化,细胞因子水平,骨质基因表达和 mitochondrial 功能的 in vitro 和 in vivo 牙周炎模型的影响.
主要成果:
- 该HA-PMs@Ce系统有效地释放了CeOx和TA作为对ROS的反应,这是牙周炎微环境的特征.
- CeOx纳米酶表现出显著的ROS清除活性,模仿超氧化物脱酶,而TA则提供抗菌作用.
- 治疗将M1巨细胞重新编程为M2表型,减少促炎细胞因子,增强骨质基因表达,恢复线粒体功能,减轻ROS引起的损伤.
- 观察到显著的炎症减弱和促进组织再生.
结论:
- 基于纳米酶的菌根平台 (HA-PMs@Ce) 提供了一个有前途的,有针对性的牙周炎治疗策略.
- 该系统有效地解决牙周炎的关键病理特征,包括氧化应激,炎症,感染和再生障碍.
- 对ROS反应的药物释放机制确保了治疗药物的有效输送到疾病部位.
更多相关视频
08:26Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
Published on: July 10, 2014
15.1K
09:35Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
Published on: September 11, 2015
9.8K
相关概念视频
01:31Osteoclasts in Bone Remodeling
3.2K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.2K
01:40Bone Remodeling
38.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.5K