在未经治疗的早产儿视网膜病变患者中使用Ranibizumab的作用
Hina Khalid1, Tayyaba Gul Malik1, Arooj Amjad1
1Post-Graduate Medical Institute/Lahore General Hospital, Clinic of Ophthalmology, Lahore, Pakistan.
Turkish journal of ophthalmology
|August 21, 2025
概括
在治疗早产视网膜病变 (ROP) 方面,静脉内拉尼比祖马布 (IVR) 初步表现出成功. 然而,所有侵袭性ROP和大多数1型ROP病例都出现了疾病的重新激活,需要进一步治疗.
科学领域:
- 眼科 眼科
- 新生儿医学
- 药理学
背景情况:
- 早产儿视网膜病变 (ROP) 是早产儿视力损伤的一个重要原因.
- 需要有效的治疗策略来预防视力丧失.
- 内拉尼祖马布 (IVR) 已成为一种潜在的治疗选择.
研究的目的:
- 评估内拉尼祖马布 (IVR) 在未经治疗的早产视网膜病变 (ROP) 的疗效.
- 评估IVR治疗后的疾病回归和救援治疗的需要.
- 为了比较攻击性ROP (AROP) 和1型ROP之间的结果.
主要方法:
- 这是一项前性研究,涉及38名患者 (76只眼睛) 接受过治疗的ROP (类型1和AROP).
- 在无菌条件下进行0. 2mg的单次静脉注射.
- 治疗后的监测时间长达6个月,并进行救援疗法 (阿贡激光光凝血) 以防疾病复发.
主要成果:
- 所有AROP病例 (56个眼睛) 需要救援治疗,平均间隔3. 43周.
- 百分之六十的ROP类型患者 (20只眼睛) 也需要激光治疗.
- 虽然没有统计学意义,但1型ROP病例的妊娠年龄略高,出生体重低于AROP病例.
结论:
- 内拉尼比祖马布 (IVR) 在ROP中提供初始疾病回归.
- 在所有AROP和60%的1型ROP病例中观察到疾病的重新激活,这表明需要救援治疗.
- 在IVR后,特别是对于AROP患者来说,频繁的随访至关重要,以控制潜在的复发.
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