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Updated: Sep 10, 2025

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
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Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

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需要MKLN1依赖的GID4/CTLH E3泛胺结合酶复合组件来支持B细胞抗体多样化

Philip Barbulescu1, Matthew K Wong1, Leon Baronian1

  • 1Department of Immunology, University of Toronto, Toronto, ON, Canada.

Journal of immunology (Baltimore, Md. : 1950)
|August 21, 2025
PubMed
概括

对于抗体多样化而言,C-终端到 LisH (CTLH) -MKLN1 E3 基因酶复合体至关重要. 它的缺失会通过增加 uracil- DNA glycosylase 2 (UNG2) 水平而损害 B 细胞的发育和 humoral 免疫力.

关键词:
B 单元格从C端到LISH美国政府类开关重组身体突变

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