大自然的盾牌:人参作为神经保护剂对二氧化纳米颗粒的暴露
Heba Abuzaied1, Dina W Bashir2, Eman Rashad2
1Cytology and Histology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt. hebaabuzaied@cu.edu.eg.
Journal of molecular histology
|August 21, 2025
概括
帕纳克斯人参对二氧化纳米颗粒 (TiO2-NP) 诱导的神经毒性具有保护性和治疗性作用. 在暴露于TiO2-NP的老鼠中,人参改善了认知功能,减少了氧化应激和脑损伤.
科学领域:
- 纳米毒理学
- 神经科学
- 药理学
背景情况:
- 二氧化纳米颗粒 (TiO2-NP) 广泛使用,但对生物系统构成风险.
- 帕纳克斯人参因其健康保护性而闻名.
- TiO2-NP可以诱导神经毒性,影响认知和情绪功能.
研究的目的:
- 在雄性大鼠中研究Panax人参对TiO2-NP诱导的神经毒性的神经保护和治疗潜力.
- 评估人参对TiO2-NPs诱导的行为,生化和组织学变化的影响.
主要方法:
- 三十五只雄性大鼠被分为五组:对照组,只有人参,只有TiO2-NP,人参保护组和人参治疗组.
- 治疗时间为30天.
- 评估包括行为测试,生物化学分析 (MDA,GSH) 和脑组织组织学/免疫化学检查.
主要成果:
- TiO2-NP暴露会影响认知能力,情绪反应和空间识别.
- TiO2- NPs增加了甲基 (MDA) 和降低了谷氨 (GSH) 水平,这表明氧化应激.
- 在接受TiO2-NP治疗的老鼠中,组织学分析显示神经元损伤和真空化,GFAP免疫反应增加.
结论:
- 在暴露于TiO2-NPs的老鼠中,使用人参改善了行为缺陷并恢复了抗氧化剂水平.
- 人参治疗减少了TiO2-NP诱导的大脑组织损伤和神经炎症.
- 帕纳克斯人参对TiO2-NP诱导的神经毒性具有显著的保护和治疗作用.
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