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在怀孕期间使用选择性血清素再吸收抑制剂的妇女的长度代谢分析

Anna Itkonen¹, Olli Kärkkäinen¹, Heidi Sahlman¹

¹School of Pharmacy, University of Eastern Finland, Yliopistonrinne 3, 70210, Kuopio, Finland.

Metabolomics : Official journal of the Metabolomic Society

|August 21, 2025

概括

在怀孕期间选择性血清素再吸收抑制剂 (SSRI) 的使用显示出母体脂质代谢的轻微变化,特别是非常低密度脂蛋白 (VLDL) 和胆米克龙亚型. 这些变化表明临床影响有限,支持在怀孕期间安全使用SSRI.

科学领域:

产科和妇科
药理学
代谢学

背景情况:

选择性血清素再吸收抑制剂 (SSRI) 通常用于怀孕期间的抑郁症.
怀孕显著改变母亲的新陈代谢,但SSRI对这种新陈代谢转变的影响在很大程度上尚未研究.
了解这些变化对于胎儿发育和母亲健康至关重要.

研究的目的:

调查SSRI在怀孕期间对母亲代谢物的影响.
评估与孕妇SSRI治疗相关的代谢物和脂蛋白的变化.

主要方法:

使用有针对性的核磁共振 (NMR) 光谱.
从怀孕的第一季度和分娩时分析了母亲的血清样本.
从SSRI使用者 (n=122) 和非抑郁症对照者 (n=117) 收集样本.

主要成果:

在怀孕的第一季度,SSRI使用与极低密度脂蛋白 (VLDL) 和胆米克龙亚型的脂质含量增加有关.
在分娩时,SSRI使用者表现出改变的脂蛋白脂和脂肪酸比率.
妊娠进展与SSRI使用相结合导致脂蛋白脂质比率降低.

结论:

在SSRI使用和母亲脂质代谢变化之间发现了显著的关联.
观察到的代谢变化很小,表明其临床意义可能有限.
这些发现有助于了解怀孕期间的SSRI安全性.

关键词:

抗抑郁药物抑郁症代谢过程代谢组有针对性的代谢组学在VLDL

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