尿路重金属负担和膀过活的风险:基于NHANES 2005-2018年的横截面研究
Jinbao Wang1,2, Qiyou Wu1,2, Bo Chen1,2
1Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
International journal of surgery (London, England)
|August 21, 2025
概括
尿路中的重金属与美国成年人的膀过活 (OAB) 风险有关. (Cd) 显示出最强的正相关性,而 (Ba) 显示出最强的负相关性.
科学领域:
- 环境健康
- 尿道病学
- 毒理学
背景情况:
- 过度活动的膀 (OAB) 影响了美国成年人口的很大一部分.
- 暴露于重金属是越来越严重的公共健康问题.
- 尿道重金属与OAB之间的具体关系尚未得到广泛研究.
研究的目的:
- 调查尿液中的重金属度与美国成年人膀过活 (OAB) 的患病率之间的联系.
- 确定可能增加或减少OAB风险的特定重金属.
主要方法:
- 使用了2005-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 通过调查问卷测量尿液中的重金属度并评估OAB.
- 使用多变量逻辑回归,非线性相关性,WQS回归和qgcomp分析.
主要成果:
- 在尿中的 (Co), (Pb), (Cd) 和 (Ur) 与OAB风险之间发现了积极的关联.
- 对 (Ba) 和 (Tl) 观察到负相关性.
- (Cd) 与OAB风险的正相关性最强,而 (Ba) 与OAB风险的负相关性最强.
结论:
- 在美国成年人中,尿液中的重金属暴露与过度活性膀 (OAB) 风险有显著联系.
- (Cd) 是主要与增加OAB风险相关的重金属.
- (Ba) 是主要的重金属,与OAB风险降低有关.
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