人类大脑脑内脑电图寿命模式的多中心规范绘制
Heather Woodhouse1, Gerard Hall1, Callum Simpson1
1CNNP Lab (www.cnnp-lab.com), Interdisciplinary Computing and Complex BioSystems Group, School of Computing, Newcastle University, Newcastle upon Tyne, UK.
Brain structure & function
|August 21, 2025
概括
这项研究使用来自许多中心的内EEG (icEEG) 数据创建了健康大脑活动的规范地图. 结果显示医院的位置和年龄显著影响大脑活动图,
科学领域:
- 神经科学
- 医学成像
- 大脑活动映射
背景情况:
- 了解健康的大脑功能对于识别病变组织至关重要.
- 之前的内EEG (icEEG) 研究往往忽略了年龄和性别的影响,样本大小也很小.
- 大脑活动的规范地图对于icEEG模式至关重要,因为它缺乏健康的对照基线.
研究的目的:
- 创建一个多中心, 规范地图的非病理大脑活动使用icEEG.
- 研究年龄,性别和医院记录对大脑活动的影响.
- 与现有文献相比,扩大主题库以获得更强大的发现.
主要方法:
- 我们使用了来自15个中心的大型队列的脑内电图记录.
- 在五个频段的相对频段功率上回归年龄和性别.
- 使用线性混合模型来考虑医院场所的影响,并评估变量的重要性.
主要成果:
- 记录医院对所有频段的规范性脑电图产生了重大影响.
- 年龄是一个比性别更有影响力的波段功率预测因素,
- 在特定区域层面上没有观察到年龄效应的特定空间模式.
结论:
- 医院的位置和年龄是影响规范性icEEG图的重要因素.
- 这些发现为未来使用规范地图在icEEG研究中的研究提供了必要的指导.
- 了解这些影响对于准确的病理组织识别至关重要.
相关概念视频
Anatomy of the Brain: Major Regions
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect various areas...
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect various areas...
Anatomy of the Brain: Ventricles
There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen. The...
Spinal Cord: Cross-sectional Anatomy
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Gray Matter and its Components
Central to the gray matter is...
Organization of the Brain
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...


