甲状腺髓癌存活率的性别差异:对4602名患者的匹配分析
Nathan Gabriel Sattah1, Vincent M D'Anniballe1, Samantha M Thomas2,3
1School of Medicine, Duke University, Durham, NC, USA.
Annals of surgical oncology
|August 21, 2025
概括
男性甲状腺癌患者的存活率明显低于女性. 这项研究表明MTC
科学领域:
- 内分泌学
- 癌症学
- 癌症研究
背景情况:
- 骨髓甲状腺癌 (MTC) 在女性中更为普遍,但在男性中表现出更强烈的攻击性.
- 基于性别的MTC结果差异的原因尚不清楚,瘤生物学或护理因素的潜在影响.
研究的目的:
- 研究甲状腺髓癌 (MTC) 结果的性别差异.
- 在考虑到临床和病理因素后,确定MTC是否表现出男性和女性的不同生存率.
主要方法:
- 利用国家癌症数据库 (2004-2020年) 来识别MTCI-IV阶段的患者.
- 根据病理阶段对应的男性和女性患者.
- 使用卡普兰-梅尔分析来估计总生存率 (OS) 和基于性别的生存率的Cox比例危险模型.
主要成果:
- 匹配了4062名患者 (2031名男性,2031名女性);年龄,种族,并发症或护理特征没有显著差异.
- 没有调整的10年生存率为女性的81. 1%,而男性的69. 6% (p < 0. 001).
- 在多变量调整后,MTC男性的死亡风险增加了81% (HR为1. 81, p < 0. 001).
结论:
- 与匹配的女性患者相比,患有甲状腺髓癌的男性患者的生存率明显较低.
- 这些发现表明基于性别的MTC瘤行为存在固有差异.
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