相关实验视频

Updated: Sep 10, 2025

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

在细胞癌中准miRNAs:新兴的治疗策略

Rabab S Hamad¹, Ghadir A Sayed², Mai A Abd-Elmawla³

¹Biological Sciences Department, College of Science, King Faisal University, 31982, Al Ahsa, Saudi Arabia. rhamad@kfu.edu.sa.

International journal of clinical oncology

|August 21, 2025

概括

微RNAs (miRNAs) 与细胞癌 (RCC) 的发展和治疗耐药性有关. 了解它们的作用可以为癌提供更好的诊断标志物和治疗方法.

科学领域:

癌症学
分子生物学
遗传学

背景情况:

细胞癌 (RCC) 往往是由于部位的转移性疾病,导致无症状瘤.
在手术后5年内出现高复发率和远程转移,这与瘤微环境的复杂性有关.
目前的向治疗和免疫疗法面临着新出现的抗药性挑战,需要改进治疗策略.

研究的目的:

审查瘤和瘤抑制微RNA (miRNAs) 在细胞癌 (RCC) 的最新发现.
探索miRNA作为RCC的诊断和预后指标的潜力.
研究miRNAs在RCC发育和治疗耐药性的作用.

主要方法:

对细胞癌 (RCC) 中微RNA (miRNA) 功能的最新研究的文献综述.
在RCC病理生理学中研究miRNA失调的研究分析.
检查miRNA与癌症进展,转移和治疗反应相关的证据.

主要成果:

微RNA (miRNA) 失调与RCC恶性病的关键方面有关,包括扩散,血管生成和转移.
改变miRNA表达会影响细胞循环动力学,细胞灭绝和RCC中的化学抵抗.
特定的miRNA显示为RCC早期检测和患者分层的生物标志物.

结论:

微RNAs (miRNAs) 在细胞癌 (RCC) 的发病和进展中起着至关重要的作用.
作为RCC的新型诊断和预后生物标志物,miRNA具有前景.
向miRNA途径可能为克服RCC治疗抵抗提供新的治疗途径.

关键词:

微RNAs (miRs,miRNAs) 的使用致癌物质细胞癌 (RCC)治疗方法瘤抑制剂

更多相关视频

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models

Published on: May 10, 2022

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Experimental RNAi

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...