大麻素对耐力运动的生理和主观反应的急性影响:剂量范围随机对照交叉试验
Ayshe Sahinovic1,2,3,4, Namson S Lau5,6, Angelo Sabag7,8
1Lambert Initiative for Cannabinoid Therapeutics, The University of Sydney, Sydney, NSW, Australia. ayshe.sahinovic@sydney.edu.au.
Sports medicine - open
|August 21, 2025
概括
在训练有素的跑步者中,大麻 (CBD) 没有显著改变耐力运动的表现或主观感受. 急性低至中等剂量的CBD不太可能提高或阻碍运动表现.
科学领域:
- 运动生理学
- 营养科学
- 药理学
背景情况:
- 运动员使用大麻素 (CBD) 恢复和管理焦虑和睡眠不足等情况.
- 对于CBD对运动表现的影响尚不清楚.
- 这项研究研究了CBD对耐力运动的生理和主观反应的急性影响.
研究的目的:
- 在耐力运动中研究低剂量 (50毫克) 和中剂量 (300毫克) 的CBD对训练有素跑步者的急性影响.
- 确定CBD是否会影响生理标记,主观体验或表现指标,
- 评估CBD在运动环境中的潜在 ergogenic 或 ergolytic 作用.
主要方法:
- 这是一项随机,双盲,安慰剂控制的交叉试验,
- 参与者在运动前1.5小时接受了0毫克 (安慰剂),50毫克或300毫克的CBD.
- 运动方案包括60分钟的低极限跑步,
主要成果:
- 无论是50毫克还是300毫克的CBD都没有改变主观反应 (例如,感知劳动力,享受) 或关键性能指标 (例如,疲劳的时间).
- 300毫克剂量降低了呼吸代谢率,而50毫克剂量增加了运动后的血糖.
- 没有观察到肌肉损伤标记的显著变化,但在50毫克的剂量下,胃肠障碍功能标记脂多糖的性别特异性相互作用被发现.
结论:
- 50毫克或300毫克CBD的急性使用似乎不会影响受过训练的跑步者的主观体验或耐力表现.
- 在这些剂量中,CBD对运动期间或运动后的生理反应具有有限的强烈影响.
- 运动员使用CBD在低至中度的急性剂量时不太可能具有机能降解作用或机能产生作用.
相关概念视频
01:16Crossover Experiments
3.0K
Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
3.0K
01:20Exercise and Cardiovascular Response
1.1K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
1.1K
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
366
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
366