多价值mopox蛋白纳米粒子疫苗提供对脊髓炎病毒感染的交叉保护
Lijun Zhang1, Chuanyu Liu1,2, Chenxi Yang1,3
1Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
PLoS pathogens
|August 21, 2025
概括
新的多价纳米颗粒可以增强对mpox病毒 (MPXV) 和其他orthopoxvirus的保护. 这些新型子单元疫苗与目前的选择相比,提供了更好的免疫反应和保护.
科学领域:
- 病毒学
- 疫苗学
- 纳米技术
背景情况:
- 2022年波克斯疫情需要先进的疫苗策略,而不仅仅是传统的活衰减疫苗病毒 (VACV) 疫苗.
- 下一代疫苗需要针对mpox病毒 (MPXV) 进行特定的,以子单位为基础的方法,以提高安全性和有效性.
研究的目的:
- 为下一代候选疫苗开发和评估具有MPXV表面抗原的自我组装蛋白质纳米粒子.
- 评估多价值纳米颗粒对MPXV和VACV挑战的免疫性和保护性.
主要方法:
- 设计了光合成蛋白纳米粒子以显示MPXV表面抗原.
- 使用精选的保护性抗原 (M1,E8,B6) 制备的单价和多价 (三价) 纳米粒子.
- 在动物模型中评估免疫反应和对致命的VACV挑战的保护.
主要成果:
- 与单价配方相比,多价纳米颗粒诱导了针对MPXV的更广泛和更强的免疫反应.
- 在动物模型中,三价纳米颗粒对致命的VACV具有优异的保护作用.
- 三价纳米颗粒引起的幽默反应超过了修饰的疫苗病毒安卡拉 (MVA),在小鼠中证实了保护.
结论:
- 多价自组合蛋白纳米颗粒代表了开发下一代针对MPXV的疫苗的有希望的平台.
- 这些纳米颗粒疫苗有可能对包括mpox和VACV在内的骨髓炎病毒提供广泛的保护.
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