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在单细胞RNA测序数据中优化免疫细胞类型名称的检测和推断

Janyerkye Tulyeu1, David Priest2, James B Wing1,2,3

  • 1Human Immunology Team, Center for Infectious Disease Education and Research, Osaka University, Suita, Japan.

Journal of immunology (Baltimore, Md. : 1950)
|August 21, 2025
PubMed
概括

由于基因脱落,在单细胞RNA测序 (scRNA-seq) 中准确识别免疫细胞具有挑战性. 通过整合专家知识和机器学习来精确地分配细胞类型,scODIN工具克服了这一问题.

关键词:
T细胞异质性退学事件免疫细胞子集机器学习scRNA-seq 在

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相关概念视频

RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...