慢性病中的阿司匹林,脂蛋白和心脏结局:慢性功能不全队列
在PubMed上查看摘要
概括
此摘要是机器生成的。低剂量阿司匹林可以通过降低心脏病发作和末期脏病的风险,对慢性脏病 (CKD) 和高脂蛋白 (Lp[a]) 患者有好处. 这种主要预防策略对于没有心血管疾病的人来说具有潜力.
科学领域
- 肝脏病学
- 心脏病学
- 药理学
背景情况
- 慢性病 (CKD) 是心血管疾病 (CVD) 的重要危险因素.
- 在CKD患者中,脂蛋白a (Lp[a]) 含量升高是常见的,并与心血管风险增加有关.
- 主要预防阿司匹林在高Lp (a) 的CKD患者中的益处仍然不确定.
研究的目的
- 研究阿司匹林使用与心血管,脏和出血结果之间的关联.
- 根据患有慢性病但没有临床心血管疾病的个体的脂蛋白 (Lp[a]) 水平来分层这些结果.
主要方法
- 对2552名从慢性功能衰竭队列中没有先前心血管疾病的参与者的分析.
- 基线Lp (a) 测量和纵向自我报告的阿司匹林使用评估.
- 考克斯比例危险回归评估阿司匹林对心肌梗塞 (MI),中风,末期脏病 (ESRD) 和严重出血的影响,分层为Lp (a) ≥50和<50 mg/ dL.
主要成果
- 在Lp (a) ≥50 mg/ dL的患者中,使用阿司匹林可降低38%的心脏病发作风险和28%的ESRD风险.
- 在Lp (a) < 50 mg/ dL组使用阿司匹林时,没有观察到显著降低心脏病发作或ESRD风险.
- 在Lp (a) 亚组中,使用阿司匹林与中风或严重出血没有显著的关联.
结论
- 患有CKD和升高的Lp (a),但没有临床心血管疾病的患者可能会从低剂量阿司匹林中受益.
- 在这种高风险的CKD人群中,阿司匹林似乎对MI和ESRD提供了初级预防的好处.
- 根据Lp (a) 的水平,进一步的研究可能会澄清慢性病患者的最佳阿司匹林使用情况.
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