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Updated: Sep 10, 2025

Improved Generation of Induced Cardiomyocytes Using a Polycistronic Construct Expressing Optimal Ratio of Gata4, Mef2c and Tbx5
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缩短和优化MEF2C和GATA4促进心脏重编程

Seiichiro Honda1, Taketaro Sadahiro2, Yuto Abe1

  • 1Department of Cardiology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba City, Ibaraki, 305-8575, Japan.

Biochemical and biophysical research communications
|August 21, 2025
PubMed
概括

优化心脏重编程因子MEF2C,GATA4和TBX5 (MGT) 通过删除非必不可少的域显著增强诱导心肌细胞 (iCM) 的产生. 这种缩短的MGT序列提高了效率,并可能促进再生医学应用.

关键词:
心脏重编程删除突变效应域转录系数

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