在AQP4+和MOG+视神经炎中视网膜质细胞功能
Katharina Messias1, Renata Moreto2, Kelvin Ferrari Corniani2
1Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil; Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Multiple sclerosis and related disorders
|August 21, 2025
概括
抗水素-4 抗体 (AQP4+) 视神经炎 (ON) 引起的视力和功能损伤比髓寡细胞糖蛋白 (MOG+) 更加严重. AQP4+ ON显示了相关的结构损失,而MOG+ ON则表明了补偿机制.
科学领域:
- 神经眼科
- 神经系统的免疫学
- 视网膜成像和电生理学
背景情况:
- 视神经炎 (ON) 可能与抗水素-4 (AQP4+) 或髓寡细胞糖蛋白 (MOG+) 的抗体有关.
- 区分AQP4+ ON和MOG+ ON对于预后和治疗至关重要.
- 视网膜质细胞功能和结构是视觉通路完整性的关键指标.
研究的目的:
- 在患有AQP4+ ON和MOG+ ON的患者中比较视网膜质细胞功能和结构.
- 研究视觉功能,视网膜结构和ON中的抗体状态之间的关系.
主要方法:
- 包括有ON病史和AQP4或MOG阳性血清检测的患者.
- 进行眼科检查,最佳校正视敏度 (BCVA),视野测试 (平均偏差,MD) 和光谱域光学连贯性断层扫描 (OCT).
- 记录了全场电视网膜学 (ERG),包括光学负响应 (PhNR),以评估视网膜质细胞功能.
主要成果:
- 与MOG+ ON眼相比,AQP4+ ON眼的BCVA显著降低,视网膜内层 (mGCL) 更薄.
- 与对照和MOG+眼相比,AQP4+ ON眼中的PhNR幅度显著降低.
- 在AQP4+ ON中,PhNR振幅与视野MD和GCL厚度相关,表明功能结构关系.
结论:
- 视力和功能障碍在AQP4+ ON中更严重,与结构损伤相关.
- MOG+ ON眼睛在结构和功能之间呈现分离,可能是由于视网膜后或中央补偿机制.
- 这些发现突出了AQP4+和MOG+ON的不同病理生理路径和临床结果.
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