多发性硬化和血管并发症患者的上肢和下肢功能差异
Heather M DelMastro1, Laura B Simaitis2, Ashley Constantine2
1Mandell Center for Multiple Sclerosis, Mount Sinai Rehabilitation Hospital, Trinity Health Of New England, 490 Blue Hills Ave., Hartford, CT, United States; Department of Rehabilitation Medicine, Frank H. Netter MD School of Medicine at Quinnipiac University, 370 Bassett Road, North Haven, CT, USA.
Multiple sclerosis and related disorders
|August 21, 2025
概括
血管并发症使多发性硬化症患者的功能恶化,特别是行走和上肢协调. 糖尿病对患有多发性硬化症 (PwMS) 的人的步行速度和行动能力产生重大影响.
科学领域:
- 神经学
- 血管医学
- 康复科学
背景情况:
- 患有多发性硬化症 (PwMS) 的人比普通人群更常见的血管并发症.
- 关于血管疾病对肢体功能影响的研究有限.
研究的目的:
- 为了比较PwMS的上肢 (UL) 和下肢 (LL) 功能.
- 确定与UL或LL功能障碍相关的特定并发症.
主要方法:
- 一个横截面研究的二次分析.
- 评估了LL功能 (定时25英尺步行,定时上升和去) 和UL功能 (手指到鼻子测试,九洞杆测试,握力,盒子和块测试).
- 使用双变量统计和调整的线性回归来分析数据.
主要成果:
- 患有血管并发症的PwMS表现较差.
- 经过协变量调整后,血管并发症与步行速度 (T25FW),移动性 (TUG) 和UL协调 (FNT) 的表现较差相关.
- 糖尿病与T25FW和TUG表现的降低有显著联系.
结论:
- 血管疾病加剧了与多发性硬化相关的步行,平衡,运动和UL协调功能缺陷.
- 糖尿病是导致步行和行动能力减弱的一个重要因素.
- 这些发现强调了血管疾病和多发性硬化病的综合影响,
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