绘制环境污染物与脂肪性肝病之间的联系:系统性审查和元分析
Xincheng Li1, Jiajing Li2, Jiangrong Zhou2
1Department of Surgery, Erasmus MC Transplant Institute, University Medical Center, Rotterdam, the Netherlands; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.
Environmental research
|August 21, 2025
概括
环境污染,包括空气污染物,内分泌干扰化学物质和重金属,显著增加了脂肪性肝病 (SLD) 的风险. 公共卫生策略对于减少暴露和预防SLD发展至关重要.
科学领域:
- 环境健康
- 毒理学
- 肝病学
背景情况:
- 环境污染是越来越严重的公共卫生问题,尤其影响新陈代谢障碍.
- 脂肪性肝病 (SLD) 是一种肝脏代谢功能障碍,影响全球超过三分之一的人口.
- 环境污染物暴露与SLD风险之间的联系尚未得到充分理解.
研究的目的:
- 系统地评估暴露于各种环境污染物和发病脂肪性肝病的风险之间的关联.
- 综合观察性研究中关于导致SLD的环境因素的证据.
- 确定与SLD发病率增加相关的特定污染物.
主要方法:
- 在Medline,Embase和Web of Science数据库中进行了全面的系统文献搜索,直到2025年5月.
- 包括观察性研究报告环境污染物和成人SLD风险的定量影响估计,遵守PRISMA和MOOSE指南.
- 使用随机效应模型汇集数据并评估整体效应估计.
主要成果:
- 分析了34项研究,将污染物分为空气污染物,内分泌破坏性化学物质 (EDC) 和重金属.
- 与颗粒物 (PM2. 5,PM10,PM1) 和二氧化 (NO2) 相关的SLD风险增加.
- 特定的EDC (双A,MECPP,MEHHP,MEOHP,PFOA) 和重金属 (,,,,) 与SLD风险增加有显著的相关性.
结论:
- 暴露于广泛的环境污染物与肥胖性肝病的风险显著增加有关.
- 这些发现凸显了旨在减少环境污染物暴露的公共卫生干预措施的迫切需要.
- 减轻环境毒素的暴露对于预防SLD的发展和进展至关重要.
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