桑格农C - 一种来自Morus alba根皮的新型抗肠球菌剂
Johannes Gafriller1, Cristina D Cruz2, Corinna Brungs3
1Division of Pharmacognosy, Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090, Vienna, Austria; Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090, Vienna, Austria.
Journal of ethnopharmacology
|August 21, 2025
概括
阿尔巴树根皮提取物对克拉姆阳性细菌具有抗菌作用. 桑格C是一种木化合物,被认为是抗Enterococcus和Staphylococcus aureus的有效药物,为抗菌药物开发提供了新的支架.
科学领域:
- 植物化学
- 药理学
- 自然产品化学
背景情况:
- Morus alba L. 根皮 (sāng bái pí) 是一种传统的中医药,用于治疗呼吸道疾病.
- 阿尔巴菌表现出广泛的抗菌性质,表明其有可能产生新型抗菌化合物.
研究的目的:
- 研究M. alba根皮提取物对ESKAPE病原体的抗菌活性.
- 确定负责观察到的抗菌作用的特定生物活性成分.
主要方法:
- 制备一种M. alba根树皮提取物 (MACEW60).
- 使用高性能逆流色谱 (HPCCC) 和分子网络 (MN) 的分离.
- 细菌生长抑制和最小抑制度 (MIC) 的微稀释测试.
主要成果:
- 这种M. alba的提取物对包括Enterococcus spp在内的格拉姆阳性细菌具有活性. 和黄金葡萄球菌.
- 桑格农C是一种木Diels-Alder类型的添加物 (MDAA),被确定为对抗E. faecalis,E. faecium和S. aureus最有效的抗菌化合物.
- 桑格C,D和O表现出抗肠球菌的活性,桑格C是最强的 (MIC为3. 125μM).
结论:
- 阿尔巴菌根树皮提取物具有显著的抗菌活性,可对抗阳性ESKAPE病原体.
- 这项研究是首次报告M. alba的抗肠球菌活性.
- 血基C和相关的MDAA代表了开发新抗菌剂对抗格拉姆阳性病原体的一类有前途的化合物.
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