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Updated: Jun 20, 2026

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
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AlphaCross-XL:一个无工具,用于自动化和蛋白质尺度映射交联到三维蛋白质结构

Sanjyot Vinayak Shenoy1, Deeptarup Biswas2, Arthur Zalevsky3

  • 1Department of Mathematics, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.

Molecular & cellular proteomics : MCP
|August 21, 2025
PubMed
概括

AlphaCross-XL自动地映射交联到蛋白质结构,使蛋白质结构的全蛋白质分析成为可能. 该工具通过与AlphaFold结构进行集成来增强交联质谱 (XL-MS).

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相关概念视频

X-ray Diffraction of Biological Samples01:10

X-ray Diffraction of Biological Samples

X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are  scattered by the electron clouds around the sample atoms. The  X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal crystal...