对抗高血压药物的双盲随机试验 (DREAM) 数据库的开发和包括试验的特征:总体审查和元分析协议
在PubMed上查看摘要
概括
此摘要是机器生成的。抗高血压药物的双盲随机试验 (DREAM) 数据库编制了1623个随机试验. 未来的分析将评估抗高血压药物对血压和安全结果的短期影响.
科学领域
- 临床药理学
- 心血管医学
- 证据综合
背景情况
- 评估短期抗高血压药物的作用对于临床实践和指导方针的制定至关重要.
- 对抗高血压药物的试验需要一个集中,全面的数据资源是显而易见的.
研究的目的
- 开发抗高血压药物的双盲随机试验 (DREAM) 数据库.
- 促进对抗高血压药物的短期疗效和安全性的系统分析.
主要方法
- 在2022年12月之前对Cochrane CENTRAL,MEDLINE和Epistemonikos数据库进行系统搜索.
- 包括2至26周的双盲随机临床试验 (RCT) 评估主要抗高血压药物.
- 根据"科克兰系统审查手册"的方法进行重复选和数据收集.
主要成果
- DREAM数据库包括1623个RCT与304,253名参与者,专注于高血压和心血管疾病.
- 很大一部分试验是安慰剂控制的 (44%) 并使用并行组分配 (70%).
- 大多数RCT (93%) 报告了血压结果,治疗时间中位数为8周.
结论
- DREAM数据库为对抗高血压药物的分析提供了坚实的基础.
- 计划中的元分析将评估血压,头痛发生率和心血管事件.
- 结果将为临床指导提供信息,并指导未来的高血压管理研究重点.
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