在成功过渡到Palbociclib的过程中,由Cyclin依赖激酶4/6抑制剂诱导的结肠炎
Ishitha Jagadish1, Phoebe Newell1, Hung Thieu Khong2
1Internal Medicine, Banner - University Medical Center Phoenix, Phoenix, Arizona, USA.
BMJ case reports
|August 21, 2025
概括
基因酶4/6抑制剂 (CDK4/6Is) 可能导致罕见的结肠炎. 这一案例凸显了在转移性乳腺癌患者中识别和管理这种药物不良反应的市场后监测的重要性.
科学领域:
- 癌症学
- 药理学
- 胃肠病学
背景情况:
- 用内分泌疗法和CDK4/ 6抑制剂 (CDK4/ 6Is) 治疗激素受体阳性 (HR+) 和人体表皮生长因子受体2阴性转移性乳腺癌.
- 利博西基布诱导的大肠炎是一种罕见的药物不良反应,发病率不明确,发表的数据有限.
- 药物诱导性结肠炎的早期发现和治疗对于患者的结果至关重要.
研究的目的:
- 在患有转移性乳腺癌的患者中报告一种罕见的 ribociclib 诱导的大肠炎.
- 描述由里博西基布诱导的大肠炎的成功治疗方法.
- 强调药物上市后对罕见不良事件的监测的重要性.
主要方法:
- 一个转移性HR+乳腺癌患者的病例研究.
- 急性腹的临床表现和肠炎的放射性发现.
- 治疗包括停止使用利博西基布,使用类固醇治疗,然后转换为palbociclib.
主要成果:
- 患者在开始服用 ribociclib 后出现了急性腹,诊断为泛结肠炎.
- 停用里博西基布和皮质类固醇治疗导致大肠炎的消失.
- 患者可以耐受另一种CDK4/ 6抑制剂palbociclib,而大肠炎没有复发.
结论:
- 这是一种罕见但严重的药物不良反应.
- 药物上市后监测对于检测和管理癌症治疗的罕见副作用至关重要.
- 需要对CDK4/ 6抑制剂诱导的大肠炎进行进一步的研究,包括比较风险和风险因素.
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