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相关概念视频

Spermatogenesis01:41

Spermatogenesis

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
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父亲暴露BDE-209通过cGAS-STING通路的激活和菌抑制扰乱了小鼠后代的精子生成.

Jinglong Xue1, Junhong Xie1, Xiangyang Li1

  • 1Department of Toxicology and Hygienic Chemistry, School of Public Health, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China.

Journal of environmental sciences (China)
|August 21, 2025
PubMed
概括

父亲暴露在甲基乙醇 (BDE-209) 中会通过损害精子和激活炎症通路来损害男性后代的生殖健康. 这种破坏精子生成和细胞分裂会影响小鼠的生育能力和健康状况.

关键词:
BDE-209 其他炎症信号通路甲状腺年老cGAS-STING的使用情况

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科学领域:

  • 环境毒理学
  • 生殖生物学
  • 分子信号

背景情况:

  • 甲基乙烯 (BDE-209) 是一种已知对男性生殖有毒的阻燃剂.
  • BDE-209对后代生殖功能的影响机制尚不清楚.

研究的目的:

  • 调查父亲BDE-209暴露对男性后代生殖系统的影响.
  • 阐明潜在的分子机制,包括DNA损伤和炎症途径.

主要方法:

  • 在50天的时间里,ICR小鼠接受了BDE-209 (75 mg/kg/day) 或对照剂 (0 mg/kg/day).
  • 在2个月和12个月的男性后代被评估精子参数,DNA损伤和丸基因表达.
  • 在体外研究中,对BDE-209治疗的小鼠精子细胞使用了cGAS抑制剂 (RU320521).

主要成果:

  • 父亲接触BDE-209会降低后代的精子数量和质量.
  • 导致ZBP1- MAVS相互作用,线粒体亡和线粒体衰变抑制.
  • 在男性后代中,抑制细胞衰老导致丸衰老.
  • 在实验室中,RU320521治疗逆转了BDE-209诱导的通路激活,亡和衰老.

结论:

  • 父亲接触BDE-209通过cGAS- STING通路激活和线粒细胞衰变抑制破坏了男性后代的精子生成.
  • 这项研究强调了BDE-209的生殖毒性及其对人口健康和生物多样性的影响.