Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cell Specific Gene Expression01:58

Cell Specific Gene Expression

13.9K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Cellular origins and etiological factors for squamous cell carcinoma and related cancer types of the bladder.

The Journal of pathology·2026
Same author

Single-cell and spatial transcriptomics uncover neoadjuvant chemotherapy-resistant malignant cells with inhibitory signalling on B cells in gastric cancer.

Clinical and translational medicine·2026
Same author

De Novo Detection of Clonal Structure and Evolution in Single-Cell and Spatial Transcriptomes.

International journal of molecular sciences·2025
Same author

Arid1a Deficiency Drives Aristolochic Acid-Induced Liver Tumorigenesis through Ctnnb1 Mutation and Defective Nucleotide Excision Repair.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Codon changes challenge PCR-based gene doping detection.

Gene therapy·2025
Same author

Liquid Guardians: Biomolecular Condensates Shield Heterochromatin Against Cellular Senescence.

BioEssays : news and reviews in molecular, cellular and developmental biology·2025
Same journal

A unified analysis of cell type- and trajectory-associated pathways in single-cell data using Phoenix.

Genome research·2026
Same journal

Resf1 is required for proper placental development and configuration of trophoblast cell-specific heterochromatin.

Genome research·2026
Same journal

Telomere-driven replicative crisis is driven by large-scale changes in genomic architecture.

Genome research·2026
Same journal

Spatially informed reference-free cell-type deconvolution for spatial transcriptomics with SpatialCD.

Genome research·2026
Same journal

Spatially resolved profiling of steroid nuclear receptors reveals a role for the disordered N-terminal domains in genome targeting and AP-1 interaction.

Genome research·2026
Same journal

Flexible and scalable inference of spatially varying correlation in spatial transcriptomics with spCorr.

Genome research·2026
查看所有相关文章

相关实验视频

Updated: Sep 10, 2025

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
10:12

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Published on: January 10, 2019

18.7K

使用DeCEP破译单细胞和空间转录组数据中的特定基因程序

Lin Li1, Xianbin Su1, Ze-Guang Han2

  • 1Shanghai Jiao Tong University.

Genome research
|August 21, 2025
PubMed
概括
此摘要是机器生成的。

DeCEP是一个新的计算框架,使用单细胞RNA测序和空间转录组数据识别特定的基因程序. 该工具通过分析转录异质性来增强对健康和疾病中的基因调节的理解.

更多相关视频

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

6.8K
Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

2.4K

相关实验视频

Last Updated: Sep 10, 2025

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
10:12

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Published on: January 10, 2019

18.7K
A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

6.8K
Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

2.4K

科学领域:

  • 基因组学
  • 计算生物学
  • 系统生物学

背景情况:

  • 功能性基因程序对细胞身份至关重要,并与各种健康和疾病有关.
  • 解读单细胞和空间分辨率的复杂基因程序是必不可少的,
  • 单细胞RNA测序 (scRNA-seq) 和空间转录组学 (ST) 为全面的基因程序表征提供了强大的工具.

研究的目的:

  • 介绍DeCEP,一个用于描述特定环境的基因程序的计算框架.
  • 利用scRNA-seq和ST数据对基因网络和程序活动进行详细分析.
  • 识别上下文依赖的枢纽基因,并将基因程序活动分配给单个细胞或空间位置.

主要方法:

  • DeCEP使用功能基因列表和定向图来构建特定细胞或空间环境的功能网络.
  • 网络拓被用来识别与基因程序相关的上下文依赖的枢纽基因.
  • 基因程序活动被分配给分析数据中的单个细胞或空间位置.

主要成果:

  • 在特定的生物背景下,DeCEP能够更细致地描述基因程序.
  • 该框架在分析具有显著转录异质性的语境方面表现出色.
  • 对模拟和真实生物数据集的评估证实了DeCEP与现有方法的互补优势.

结论:

  • DeCEP提供了一个强大的计算方法来剖析特定环境的基因程序.
  • 这种框架有助于对阿尔茨海默氏症和癌症等复杂疾病进行更深入的生物学洞察.
  • DeCEP促进了对正常组织和疾病状态的基因调节的理解.