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血清甲基马龙酸与认知能力低下之间的关联

Ziping Wang¹, Yan Deng², Liangkai Chen³

¹Department of Nutrition, Hygiene and Toxicology (ZW, BL, TW, SR), Academy of Nutrition and Health, School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan, China.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

|August 21, 2025

概括

甲基马龙酸 (MMA) 的较高水平与老年人的认知功能较差有关,尤其影响语言和注意力. 这一发现可能为预防与年龄相关的认知衰退提供新的见解.

科学领域:

老年学
神经科学
生物化学

背景情况:

甲基酸 (MMA) 积累越来越多地被认为是其在衰老和癌症中的作用.
关于MMA与老年人与年龄相关的认知衰退之间的联系的研究有限.
了解这种联系可以为预防痴呆症等认知障碍制定策略.

研究的目的:

研究血清甲基马龙酸 (MMA) 水平与老年人的认知功能之间的关联.
探索MMA与特定的认知领域之间的关系,包括记忆,语言和注意力.
为MMA在与年龄相关的认知衰退中的潜在作用提供证据.

主要方法:

分析了来自国家健康和营养调查的2,760名老年人的数据.
使用气色谱/质谱测量测量血清MMA度.
通过评估即时记忆,延迟记忆,语言和注意力的神经心理测试来评估认知功能,以及全球认知和自我报告的主观认知衰退.
应用加权线性和逻辑回归模型来确定MMA和认知结果之间的关联.

主要成果:

较高的MMA水平与较差的认知功能有关,特别是在语言和注意力领域.
逻辑回归表明,MMA≥250nmol/ L的个体与MMA<170nmol/ L的个体相比,具有较低的全球认知 (OR: 1.53),语言功能 (OR: 1.56) 和注意力 (OR: 1.48) 的几率增加.
多变量线性回归显示MMA与全球认知得分 (β: -1. 84) 和注意力 (β: -2. 06) 之间存在显著的反向关联.

结论:

循环中的甲基马龙酸 (MMA) 与全球认知,语言功能和老年人注意力相反相关.
需要进一步研究以阐明MMA与认知功能之间的因果关系和潜在的生物机制.
这些发现凸显了MMA作为与年龄相关的认知衰退的潜在生物标志物.

关键词:

认知功能甲基马龙酸年长的成年人维生素B12

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