用于预防乳腺癌的十字植物,生物活性代谢物和微生物组
Emily Ho1,2, Carmen P Wong1,2, John A Bouranis1,2
1School of Nutrition and Public Health, Oregon State University, Corvallis, Oregon, USA; email: emily.ho@oregonstate.edu, carmen.wong@oregonstate.edu, ybouranis96@gmail.com.
Annual review of nutrition
|August 21, 2025
概括
富含硫黄素 (SFN) 和印醇-3-碳醇 (I3C) /DIM的十字花蔬菜在预防和治疗乳腺癌方面具有潜力. 肠道微生物组的相互作用可能会影响它们的有效性,建议采用个性化的方法.
科学领域:
- 癌症学
- 营养科学
- 微生物组研究
背景情况:
- 乳腺癌是一种复杂的疾病,具有不同的亚型和治疗反应.
- 十字花蔬菜含有生物活性化合物,如硫黄 (SFN) 和印-3-碳醇 (I3C) /3,3'-二甲 (DIM),具有潜在的抗癌特性.
研究的目的:
- 对SFN,I3C和DIM在乳腺癌中的疗效进行最近的人类和临床前研究.
- 探索肠道微生物组在调节十字花蔬菜和乳腺癌治疗中的作用.
- 确定包含植物化学物质和常规治疗的有希望的组合治疗策略.
主要方法:
- 对乳腺癌风险,预后和治疗中的SFN,I3C和DIM进行的人类研究的系统审查 (至2024年).
- 评估植物化学品与标准疗法的协同效应的临床前研究 (2018-2024年).
- 分析肠道微生物对葡萄糖酸代谢和乳腺癌的研究影响.
主要成果:
- 最近的人类研究表明,SFN,I3C和DIM在乳腺癌治疗中的潜在益处.
- 临床前数据表明,当将这些植物化学物质与常规治疗相结合时,有望产生协同效应.
- 肠道微生物组合的个体间变化可能会影响十字植物化合物的代谢和治疗疗效.
结论:
- 考虑到个体微生物组的特征,将十字花蔬菜及其生物活性化合物整合为乳腺癌治疗提供了一个有前途的补充策略.
- 考虑微生物组与宿主相互作用的个性化方法可能会增强饮食干预和标准治疗的益处.
- 需要进一步的临床试验来验证这些组合治疗策略.
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