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LYMTACs:化学小分子为目标蛋白重新定位和降解重新使用 lysosomal 膜蛋白

Dhanusha A Nalawansha1, Georgios Mazis2, Gitte Husemoen2

  • 1Induced Proximity Platform, Amgen Research, Thousand Oaks, CA, USA. dnalawan@amgen.com.

Nature communications
|August 21, 2025
PubMed
概括

研究人员开发了一种新型的小分子平台 - - LYsosome Membrane TArgeting Chimeras (LYMTACs). LYMTACs针对膜蛋白进行 lysosomal 降解,提供控制致癌基因的新途径.

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