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Updated: Sep 10, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

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破坏TCR信号传递-LAG3干扰CD3ε-LCK相互作用

Gina J Fiala1, Wolfgang W Schamel2,3

  • 1Signalling Research Centres BIOSS and CIBSS, and Department of Immunology, Insitute of Biology III, Faculty of Biology, University of Freiburg, Freiburg im Breisgau, Germany.

Cell research
|August 21, 2025
PubMed
概括

No abstract available in PubMed .

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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