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口服的atogepant减轻了老鼠传播脱极化引起的疼痛和焦虑行为

Melih Z Kaya¹, Pradeep Banerjee², Cenk Ayata¹

¹Department of Neurology, Neurovascular Research Unit, Massachusetts General Hospital, 149 13th Street, Charlestown Rm 6.215, Boston, MA, 02129, USA.

The journal of headache and pain

|August 21, 2025

概括

扩散脱极化 (SD) 在小鼠中引起面部疼痛和焦虑. 口服的atogepant是一种CGRP受体对抗剂,显著降低了这些疼痛和焦虑行为,表明对偏头痛的治疗潜力.

科学领域:

神经科学
疼痛研究
药理学

背景情况:

扩散脱极化 (SD) 有关偏头痛光环和三胞胎视觉.
在小鼠中,光遗传诱导SD (opto-SD) 导致周围轨道机械.
这项研究调查了CGRP受体对抗是否可以缓解SD引起的疼痛和焦虑.

研究的目的:

评估口服的atogepant对缓解SD诱导的疼痛和焦虑表型的疗效.
探索CGRP信号在SD相关的三胞胎疼痛途径中的作用.

主要方法:

在Thy1-ChR2-EYFP转基因小鼠中的光遗传性SD诱导.
在opto- SD前一个小时,通过口腔测量剂给予atogepant (30 mg/ kg) 或载体.
评估周围轨道机械形,面部微笑 (PainFace) 和类似焦虑的行为 (开放场地测试).

主要成果:

Opto-SD显著降低了周围轨道的机械值,增加了面部微笑和thigmotaxis.
阿托杰潘特治疗缓解了SD诱导的形,并消除了面部微笑.
此外,Atogepant还可以缓解SD引起的焦虑性行为 (thigmotaxis).

结论:

在小鼠中预先使用atogepant可缓解SD引起的面部疼痛和类似焦虑的行为.
这些发现支持CGRP在SD中介疼痛中的作用,并建议atogepant作为对偏头痛aura的潜在治疗方法.

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