在巴西队列中与中断的暴露前预防 (PrEP) 相关的因素:简要信息
Patricia Matias Pinheiro1,2, Nathalia Pedrosa Lima1,3, Angelica Espinosa Miranda4
1Graduate Program in Tropical Medicine, School of Medicine, University of Brasília, Distrito Federal, Brasília, Brazil.
AIDS research and therapy
|August 21, 2025
概括
巴西的艾滋病毒暴露前预防 (PrEP) 中断与先前的门病变,早期感染和忘记服用药物有关. 加强早期支持对于PrEP的持续性至关重要.
科学领域:
- 公共卫生
- 传染病流行病学
- 预防艾滋病毒
背景情况:
- 暴露前预防 (PrEP) 是预防艾滋病毒的关键生物医学干预措施.
- 了解影响PrEP停药的因素对于优化公共卫生计划的有效性至关重要.
- 巴西统一卫生系统 (SUS) 提供PrEP,
研究的目的:
- 在巴西的艾滋病毒预防使用者中确定与停止暴露前预防 (PrEP) 相关的因素.
- 为改善巴西医疗保健系统中的PrEP遵守和长期使用提供信息.
主要方法:
- 一项分析病例控制研究利用了2018-2020年的追溯数据.
- 暂停PrEP的病例 (n=629) 与维持PrEP的对照病例 (n=6290) 相比为10%.
- 后勤回归分析发现了 PrEP 停药的重要预测因素.
主要成果:
- 以前的门病变 (aOR: 1. 92),在开始PrEP后的30天内发生的活跃感染 (aOR: 1.51),以及频繁的药物忘记 (aOR: 1.48) 与停止治疗有关.
- 第一个月没有不良反应是保护性的 (aOR: 0. 73).
- 停止使用PrEP的中位时间为8个月.
结论:
- 早期的临床经验和坚持的行为显著影响了PrEP的延续.
- 在使用PrEP的最初30天内加强支持和监测对于改善持久性至关重要.
- 需要有针对性的干预措施来解决导致巴西PrEP停药的因素.
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