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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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用于治疗创伤性骨髓炎的双抗生素PLGA微球

Liangguo Si1, Wenping Zhang2, Haifeng Jiang2

  • 1School of Clinical Medicine, Ningxia Medical University , 750004, Yinchuan, China.

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新的聚乳糖酸微球 (PLGA) 含有莫西素/ 里法素有效治疗创伤性骨髓炎. 这些微球显示出极好的安全性和抗菌效果,

关键词:
PLGA, 莫西弗洛克萨辛, 里芬皮辛, 骨髓炎, 局部药物输送, MRSA

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科学领域:

  • 生物材料科学
  • 传染性疾病
  • 药物输送系统

背景情况:

  • 创伤性骨髓炎 (TO) 存在重大治疗挑战,主要是由于细菌生物膜的形成和抗生素进入感染部位的不足.
  • 目前的治疗策略往往难以有效消灭细菌,导致慢性感染和长期患者的痛苦.

研究的目的:

  • 开发和评估与莫西素和利芬素 (M/R-P) 共同装载的聚乳糖酸 (PLGA) 微球,用于局部治疗创伤性骨髓炎.
  • 在创伤性骨髓炎模型中评估M/R-P微球的安全性,细胞兼容性和体内抗菌疗效.

主要方法:

  • 这些PLGA微球是为了同时加载莫西弗洛克萨辛和里法素而制成的.
  • 试验室评估包括细胞毒性测定 (CCK-8,活/死染色,SEM) 和骨质性潜力的评估 (ALP活性).
  • 在相关动物模型中通过细菌负荷量化 (CFU/ g) 和通过组织病理学评估感染解消来确定体内疗效.

主要成果:

  • 实验室研究证实M/ R- P微球没有细胞毒性,也没有抑制骨质生成潜力.
  • 在体内,M/R-P微球显著降低了MRSA细菌负担,相比只有除菌的对照 (8 ± 3 × 103 CFU/g与3143 ± 727 × 103 CFU/g;p < 0.0001).
  • 在M/ R- P微球治疗组中,组织病理学分析显示感染几乎完全消失.

结论:

  • 开发的M/R-P微球显示出出色的安全性,良好的细胞兼容性,以及对创伤性骨髓炎的显著抗菌功效.
  • 在慢性骨髓炎中,PLGA微球是局部抗生素治疗的可行且有效的药物输送载体.
  • 这种创新方法为克服与创伤性骨髓炎治疗相关的临床挑战提供了新的战略方向.