临床和实验室预测病例的死亡率
Deniz Borcak1, Yusuf Emre Ozdemir2, Zuhal Yesilbag3
1Department of Infectious Diseases and Clinical Microbiology, Bakırköy Dr.Sadi Konuk Training and Research Hospital, Istanbul, Turkey. drdenizborcak@gmail.com.
Scientific reports
|August 21, 2025
概括
中性球与淋巴细胞比率 (NLR) 升高,C反应蛋白 (CRP) 升高和白蛋白降低预示着白血球菌病 (SAB) 的死亡率. 早期诊断和治疗对于减少感染死亡至关重要.
科学领域:
- 传染性疾病
- 临床微生物学
- 流行病学
背景情况:
- 黄金葡萄球菌 (SAB) 是医院感染的重要原因.
- 了解流行病学和临床特征对于改善患者的结果至关重要.
- 在接受非重症监护的SAB患者中预测死亡率需要进一步的研究.
研究的目的:
- 描述SAB患者的流行病学和临床特征.
- 在SAB患者中确定30天和住院死亡率的预测因素.
- 加强SAB的患者管理策略.
主要方法:
- 356名SAB住院患者 (2016-2024) 的单中心回顾性研究.
- 从电子病历中获取临床和微生物学数据.
- 使用多变量和考克斯回归分析以及ROC曲线来确定死亡率预测因素.
主要成果:
- 30天和住院死亡率分别为7. 3%和9. 8%.
- 30天死亡率的预测因素包括中性粒细胞与淋巴细胞的比率升高 (NLR),C反应蛋白 (CRP) 和白蛋白的降低.
- 死亡的重要风险因素是肺炎,白血病和败血症;住院死亡的独立风险因素是年龄,白血病和低白蛋白.
结论:
- 较高的NLR,CRP和较低的白蛋白水平与SAB患者的死亡率增加有关.
- 肺炎,白血病和败血症是死亡的重要危险因素.
- 早期诊断和适当的抗生素治疗对于降低SAB死亡率至关重要.
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